SUMMARY

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Within the goals of the UC Davis Superfund Center, this project will investigate new mechanistic insights into the effects of chronic exposure of Superfund (SF) chemicals on endoplasmic reticulum (ER) stress, which leads to fibrosis and organ damage. Recent and exciting data demonstrate that exposure to xenobiotics perturbs the levels of P450-generated lipid mediators, which directly affect the pathological development of ER stress. Thus, this project will directly test the novel hypothesis that plasma lipid mediators may represent a surrogate biomarker for ER stress following chronic xenobiotic exposure, as well as developing a new cell-based bioassay for quantitation of pro-ER stress environmental toxicants in field samples.